The smart Trick of ceesdekker.net That Nobody is Discussing
The smart Trick of ceesdekker.net That Nobody is Discussing
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Nanotechnology gives A selection of alternatives to contribute to biology. Listed here I will current illustrations where nanofabrication – the chance to make confined constructions with dimensions at will – is utilised to look at the biophysics of one molecules and cells. I'll existing some illustrations from our lab:
Our group studies bacterial mobile division and is also aiming to constitute a ‘bottom up biology’ in artificial cells which will autonomously divide. Our major curiosity lies in cell division, chromatin composition, and spatial Regulate.
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Nanofabrication of electrodes with sub-5 nm spacing for transportation experiments on single molecules and metallic clusters
2010, made a new way (‘wedging transfer’) to manipulate nanostructures; 1st report of DNA translocation by graphene nanopores; and understood hybrid nanopores by directed insertion of α-hemolysin into solid-state nanopores
Cornelis (Cees) Dekker (Haren, seven april 1959) is een Nederlandse natuurkundige en universiteitshoogleraar verbonden aan de Technische Universiteit Delft. Van 2010 tot en fulfilled 2018 was hij tevens directeur van het Kavli Institute of Nanoscience in Delft. Zijn vakgebied is de moleculaire biofysica; hierbij beweegt hij zich op het grensvlak van de natuurkunde en de biologie waarbij hij gebruikmaakt van de zogeheten nanotechnologie, de technieken om aan enkele atomen en moleculen te kunnen meten.
We use nanofabricated microfluidic buildings to sample spatial boundaries for micro organism and biomimetic vesicles with reconstituted protein networks which assess the basic part of spatial confinement on the molecular and cellular level. Our projects involve the following:
Dynamic ParB–DNA interactions initiate and sustain a partition condensate for bacterial chromosome segregation
Imagine if, as an alternative to utilizing traditional leading-down silicon electronics, transistors can be created from The underside up employing one natural molecules given that the switching aspects? This idea, which turned The idea of now’s discipline ceesdekker.net of molecular electronics, first emerged while in the nineteen seventies.
Resolving the phase sizing in condensin-driven DNA loop extrusion identifies ATP binding as the action-building system
FtsZ treadmilling is essential for Z-ring condensation and septal constriction initiation in bacterial cell division
2001, discovery of single-electron transistors at space temperature depending on nanotubes; realization of initially logic circuits with carbon nanotube equipment; and discovery of your molecular structure of DNA repair enzymes with AFM
Developments in nanotechnology within the 1990s created creating electronic gadgets from single molecules a chance. Cees Dekker recounts how his group developed a space-temperature transistor depending on just one carbon nanotube.
2004, discovery of latest physics in translocation of DNA through nanopores; initially experimental examine of ions conduction in nanofluidic channels; initial electrochemistry with individual solitary-wall carbon nanotubes; STM detection and control of phonons in carbon nanotubes; to start with electrical docking of microtubules on kinesin-coated nanostructures; 1st biophysics characterization in the mechanical properties of double-stranded RNA; and initially single-molecule review of DNA translocation by a restriction-modification enzyme.